Hematology billing must account for complex treatment protocols, including the administration of specialized medications, infusions, and lab work, which often involve intricate billing regulations and preauthorization requirements. Insurance types such as Medicare, Medicaid, and private insurers each have distinct rules for coverage, especially when it comes to high-cost treatments like chemotherapy and targeted therapies. Ensuring compliance with payer-specific guidelines, managing denials and appeals, and accurately documenting services are critical for securing timely reimbursements. Effective hematology billing helps practices optimize revenue, ensuring that patients with serious blood disorders receive necessary treatments without financial interruptions to care.